Wednesday, July 31, 2019

Medical Immunology

MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday, RMT, MT(ASCPi), MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective †¢ 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled †¢ 1798, Edward Anthony Jenner, Smallpox vaccination †¢ 1862, Ernst Haekel, Recognition of phagocytosis 1877, Paul Erlich, recognition of mast cells Historical Perspective †¢ 1879, Louis Pasteur, Attennuated chicken cholera vaccine development †¢ 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination †¢ 1885, Pasteur discovered therapeutic vaccination; first report of live â€Å"attenuated† vaccine for rabies Historical Perspective 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) †¢ 1888, George Nuttall, Bactericidal action of blood †¢ 1 890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity †¢ 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity †¢ 1894, Richard Pfeiffer, Bacteriolysis Historical Perspective (1 of 6 ) 1895, Jules Bordet, Complement and antibody activity in bacteriolysis †¢ 1900, Paul Ehrlich, responsible for the antibody formation theory †¢ 1901, Karl Landsteiner, A, B, and O †¢ 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors †¢ 1902, Paul Portier & Charles Richet, Anaphylaxis Historical Perspective (1 of 6 ) †¢ 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity †¢ 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin †¢ 1906, Clemens von Pirquet, coined the word allergy †¢ 1907, Svante Arrhenius, coined the term immunochemistryHistorical Perspective †¢ 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups †¢ 1910, Peyton Rous, Viral immunology theory †¢ 1914, Clarence Little, Genetics theory of tumor transplantation †¢ 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains Historical Perspective †¢ 1917, Karl Landsteiner, Haptens †¢ 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions †¢ 1924, L. Aschoff, Reticuloendothelial system †¢ 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation †¢ 1938, John Marrack, Antigen-antibody binding hypothesis Historical Perspective 1936, Peter Gorer, Identification of the H2 antigen in mice †¢ 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens †¢ 1941, Albert Coons, Immunofluorescence technique †¢ 1942, Jules Freund & Katherine McDermott, Adjuvants †¢ 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis) Historical Perspective †¢ 1944, Peter Medwar, Immunological hypothesis of allograft rejection †¢ 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells †¢ 1948, George Snell, Congenic mouse lines †¢ 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesisHistorical Perspective †¢ 1950, Richard Gershon and K Kondo, Discovery of supressor T cells †¢ 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) †¢ 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction †¢ 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells Historical Perspective †¢ 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis †¢ 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory †¢ 1957, Ernest Witebsky et all. Induction of autoimmunity in animals †¢ 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine) Hi storical Perspective †¢ 1958-62, Jean Dausset et al. , Human leukocyte antigens †¢ 1959-62, Rodney Porter et al. , Discovery of antibody structure †¢ 1959, James Gowans, Lympocyte circulation †¢ 1961-62, Jaques Miller et al. , Discovery of thymus involvement in cellular immunity †¢ 1961-62, Noel Warner et al. , Disctinction of cellular and humoral immune response Historical Perspective †¢ 1963, Jacques Oudin et al. Antibody isotypes †¢ 1964-68, Anthony Davis et al. , T and B cell cooperation in immune response †¢ 1965, Thomas Tomasi et al. , Secretory immunoglobulin antibodies †¢ 1967, Kimishige Ishizaka et al. , Identification of IgE as the reaginic antibody Historical Perspective †¢ 1971, Donald Bailey, Recombinant inbred mouse strains †¢ 1972, Gerald M. Edelman & Rodney Porter, Identification of antibody molecule †¢ 1974, Rolf Zinkernagel & Peter Doherty, MHC restriction †¢ 1975, Kohler and Milstein, First monoclona l antibodies used in genetic analysisHistorical Perspective †¢ 1984, Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting †¢ 1985, Tonegawa, Hood et al. , Identification of immunoglobulin genes †¢ 1985-1987, Leroy Hood et al. , Identification of genes for the T cell receptor †¢ 1986, Monoclonal hepatitis B vaccine Historical Perspective †¢ 1986, Mosmann, Th1 versus Th2 model of T-helper-cell function †¢ 1990, Yamamoto et al. Molecular differences between the genes for blood groups O and A and between those for A and B †¢ 1990, NIH team, Gene therapy for SCID using cultured T cells †¢ 1993, NIH team, Treatment of SCID using genetically altered umbilical cord cells Historical Perspective †¢ 1996-1998, Identification of toll-like receptors †¢ 2001, FOXP3, the gene directing regulatory-T-cell development †¢ 2005, Frazer, Development of human papilloma-virus vaccine Th e IMMUNE SYTEM What is Immunology? †¢ Study of the molecules, cells, organs, and systems responsible for the recognition and disposal of foreign (nonself) material †¢ †¦ ow body components respond and interact †¢ †¦desirable and undesirable consequences of immune interactions †¢ †¦ways in which the immune system can be advantageously manipulated to protect against or treat disease What is Immunity? †¢ Latin word â€Å"immunitas†, freedom from †¢ It refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. †¢ Can be either natural (innate or inborn) or acquired (adaptive) Function of the Immune System †¢ Recognize â€Å"self† from â€Å"nonself† †¢ Defend the body against nonself Physiologic function is to prevent infection and to eradicate established infections (sterilizing immunity) Key Characteristics of the Immune System †¢ Innate immunit y †¢ Primary response †¢ Secondary response and immunologic memory †¢ Immune response is highly specific †¢ Immune system is tolerant of self-antigens †¢ Immune responses against self-antigens can result in autoimmune diseases †¢ Immune responses against infectious agents do not always lead to elimination of the pathogen (HIV/AIDS) Major Principles of Immunity (immune response): Elimination of many microbial agents through the nonspecific protective mechanisms of the innate immune system. †¢ Cues from the innate immune system inform the cells of the adaptive immune system as to whether it is appropriate to make a response and what type of response to make. Major Principles of Immunity (immune response): †¢ Cells of the adaptive immune system display exquisitely specific recognition of foreign antigens and mobilize potent mechanisms for elimination of microbes bearing such antigens. The immune system displays memory of its previous responses. à ¢â‚¬ ¢ Tolerance of self-antigens. Cells of the Immune System †¢ Lymphocytes – occupy the central stage; determines the specificity of immunity †¢ Dendritic cells (DCs) & Langerhan cells †¢ Monocyte/macrophages †¢ Natural killer (NK) cells †¢ Neutrophils †¢ Mast cells & Basophils †¢ Eosinophils †¢ Epithelial and stromal cells – provides anatomic environment (secretion of critical factors that regulate migration, growth and homeostasis) Lymphoid Tissues and Organs Primary Lymphoid Organs Sites where pre-B and pre-T lymphocytes mature into naive T and B cells in the absence of foreign antigen; †¢ Fetal Liver, Adult bone marrow, and thymus The INNATE IMMUNE SYTEM INNATE IMMUNE SYSTEM †¢ relies on germ line-encoded receptors to detect a limited set of microbial structures that are uniquely associated with microbial infection †¢ not a function of a single defined physiologic system; rather, it is a product of multiple a nd diverse defense mechanisms Modules of the Innate Immune System †¢ Surface epithelium The phagocyte system – critical for the defense against both intracellular and extracellular bacteria as well as fungal pathogens; aided by opsonins †¢ Acute phase response and complement – variety of secreted proteins that function in the circulation and in tissue fluids; secreted by the hepatocytes in response to the inflammatory cytokines IL1 and IL-6 Modules of the Innate Immune System †¢ Natural killer (NK) cells are specialized in the elimination of infected host cells and in aiding defense against viral and other intracellular infections through production of cytokines(IFN-? ; regulated by type I interferons (IFN-? /? ) †¢ Mast cells, eosinophils, and basophils are specialized in defense against multicellular parasites, such as helminthes; regulated by several cytokines, including IL-4, IL-5, IL-9, and IL-13 Strategies of Innate Immune Recognition 1. Recog nition of microbial nonself – referred to as pattern recognition, based on the recognition of molecular structures that are unique to microorganisms and not produced by the host 2.Recognition of missing self – based on the recognition of molecules expressed only on normal, uninfected cells of the host Targets of Innate Immune Recognition †¢ PAMPs (pathogen-associated molecular patterns) – molecular structures produced by microbial pathogens, but not by the host organism †¢ PRRs (pattern recognition receptors) – receptors of the innate immune system and represents targets of the innate immune system Targets of Innate Immune Recognition Examples of PAMPs include: (1) LPS of gram-negative bacteria (2) LTA of gram-positive bacteria (3) Peptidoglycans (4) Lipoproteins of bacteria (cell wall) (5) Lipoarabinomannan of mycobacteria (6) dsRNA produced by virus during the infection cycle (7) ? -glucans and mannans found in fungal cell wall Receptors of th e Innate Immune System †¢ Broad categories of PRRs: (1) PRRs that signal the presence of infection; expressed on the cell surface or intracellularly Categories of gene products: a. proteins and peptides that have direct antimicrobial effector functions (antimicrobial peptides and lysozyme) b. nflammatory cytokines and chemokines (TNF, IL-1, IL-8) c. gene products that control activation of the adaptive immune response (MHC, CD80/CD86, IL-12) Receptors of the Innate Immune System †¢ Broad categories of PRRs: (2) Phagocytic (or endocytic) PRRs; expressed on the surface of macrophages, neutrophils, and dendritic cells(DCs) (3) Secreted PRRs (mannan-binding lectin and peptidoglycan-recognition proteins Function: a. activate complement b. opsonize microbials cells to facilitate their phagocytosis c. ccessory proteins for PAMP recognition by transmembrane receptors (TLR) Receptors of the Innate Immune System †¢ Toll-like Receptors – comprise a family of type 1 transm embrane receptors characterized by leucine rich repeats (LRRs) in the extracellular portion and an intracellular TIR (Toll/IL-1 receptor) domain; grouped into two classes: (1) TLRs 1, 2, 4, 5, and 6 are expressed on the plasma membrane and detect bacterial and fungal cell wall components; (2) TLRs 3, 7, and 9 are expressed in endosomal compartments and recognize viral nucleic acidsToll-like receptor 4 (TLR4) †¢ expressed predominantly in the cells of the immune system, including macrophages, DC, neutrophils, mast cells, and B cells †¢ also expressed on endothelial cells, fibroblasts, surface epithelial cells, and muscle cell †¢ Signal transducing receptor for LPS, heat sensitive protein associated with the cell walls of MTB †¢ Together with CD14 shown to mediate responsiveness to the fusion (F) protein of RSVToll-like receptor 2 (TLR2) †¢ Involved in recognition of LTA and peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprot ein, mycobacterial lipoarabinomannan, a phenol-soluble modulin from S. epidermidis, zymosan of yeast cell walls, and lipoglycosylphosphotidylinositol T. cruzi †¢ Also shown to recognize two kinds of atypical LPS: L. interrogans and Porphyromonas gingivitis Toll-like receptor 3 (TLR3) Receptor for dsRNA †¢ Can mediate responses to poly(IC) †¢ Expressed on DCs, macrophages, and surface epithelial cells, including instestinal epithelium †¢ Also expressed in CD8+ DCs Toll-like receptor 7 (TLR7) †¢ Involved in viral recognition and both detect nucleic acids together with TLR9 †¢ Recognizes viral ssRNA (derived from RNA viruses); TLR9 (unmethylated DNA derived from DNA viruses) †¢ Expressed primarily on plasmacytoid dendritic cells †¢ Activated by small antiviral compunds, e. g. imiquinoid †¢TLR7-mediated recognition takes place inside the late lysosomes Toll-like receptor 9 (TLR9) †¢ Involved in the antiviral host defense; especially on r ecognition of DNA viruses (HSV) †¢ Expressed in type-I INF-producing plasmacytoid DCs Phagocytic Receptors †¢ Scavenger receptors – cell-surface glycoproteins that are defined by their ability to bind to modified LDL †¢ Macrophage Mannose Receptor (MR) – type I transmembrane protein expressed primarily in macrophages; involved in phagocytosis of bacterial (MTB, P. eruginosa, K. pneumonia), fungal (S. cerevisae, C. albicans), and protozoan pathogens (P. carinii) Cells of the Innate Immune System †¢ Macrophages – most central and essential functions and have multiple roles in host defense (e. i. â€Å"housekeeping functions†); in red pulp of the spleen, it phagocytose and remove from circulation senescent RBCs †¢ Neutrophils †¢ Mast Cells – best known effectors of allergic response; protective role is by rapid production of TNF-? nd leukotriene B4 (neutrophil recruitement) Cells of the Innate Immune System †¢ Eosino phils – found primarily in the respiratory, intestinal, and genitourinary tracts; contains cationic effector proteins toxic to parasitic worms; poor phagocytes †¢ Dendritic Cells – immature DCs reside in peripheral tissues and are highly active in macropinocytosis and receptor-mediated endocytosis; expresses PRRs and TLRs; have roles in the initiation of adaptive immune response Cells of the Innate Immune System Suface Epithelium – lines the mucosal surfaces of the intestinal, respiratory, and genitourinary tracts provide an important physical barrier The Effector Mechanisms of the Innate Immune System The Major Categories of Antimicrobial Effector Enzymes that hydrolyze components of microbial cell walls Antimicrobial proteins and petides that disrupt the integrity of microbial cell walls †¢ Lysozyme †¢ Chitinases †¢ Phospholipase A2 †¢ †¢ †¢ †¢ †¢ BPI Defensins Cathelicidins Complement Eosinophil cationic protein Mi crobicidal serine proteasesProteins that sequester iron and zinc Enzymes that generate toxic oxygen and nitrogen derivatives †¢ Seprocidins †¢ Lactoferrin †¢ NRAMP †¢ calprotein †¢ Phagocytic oxidase †¢ Nitric oxide synthase †¢ myeloperoxidase The Effector Mechanisms of the Innate Immune System †¢ Lysozyme – a. k. a. muramidase; degrades the peptidoglycan of some gram(+) bacteria; highly concentrated in secretions such as tears and saliva †¢ Chitinases – enzymes that degrade chitin; secreted by activated macrophages and presumably play a role in antifungal defenseThe Effector Mechanisms of the Innate Immune System †¢ Defensins – cationic peptides with a broad spectrum of antimicrobial activities against gram(+) and gram(-) bacteria, fungi, parasites, and some envelope viruses; kill microorganisms by forming pores in the membranes; divided into ? – and ? defensins †¢ ? -defensins – presynthesize d and stored in granules of neutrophils and Paneth cells of the small intestine †¢ ? -defensins – produced by epithelial cells and not stored in cytoplasmic granulesThe Effector Mechanisms of the Innate Immune System †¢ Cathelicidins – active against gram(+) and gram(-) bacteria and fungi; produced in neutrophils and stored as inactive proproteins in the secondary granules †¢ Serprocedins – comprise a family of cationic serine proteases with antimicrobial activity (neutrophil elastase, proteinase 3, cathepsin G, and azurocidin); exert its antimicrobial activity by either perturbation of microbial membranes or by proteolysisThe Effector Mechanisms of the Innate Immune System †¢ Lactoferrin, NRAMP, and Calprotectin – antimicrobial activities are due to the ability to sequester iron and zinc †¢ Lactoferrin – found in the secondary granules of neutrophils, in epithelial secretions (e. i. breast milk), in the intestinal epitheli um of infants, and in airway fluids; bacteriostatic (iron sequestration) and bacteriocidal (perturbation of microbial membranes) The Effector Mechanisms of the Innate Immune System NRAMP (natural resistance-associated macrophage protein) – integral membrane protein that functions as an ion pump in the phagocytic vacuoles of macrophage and neutrophils †¢ Calprotectin – member of the family of calciumbinding proteins; microbial activity is by chelation and sequestration of zinc ion ACUTE PHASE REACTANTS †¢ Soluble factors which are normal constituents that increase or decrease rapidly as produ †¢ Not a function of a single defined physiologic system; rather, it is a product of multiple and diverse defense mechanisms

Tuesday, July 30, 2019

Stephen Crane’s The Bride Comes to Yellow Sky

Upon reading Stephen Crane’s (91) The Bride Comes to Yellow Sky, the initial reaction was surprise. In the climax of the story, there was no gun slinging, no gun shot, and no body dropping on the ground. It seems to be a different kind of Western from those usually read in novels and seen in the movies. Yet, upon a greater examination of the story, it would become clear that Crane is portraying a different kind of Western—one in which he delights his readers and at the same time shows a different face of the men in a western setting (Petry 45).This paper seeks to look at the short story and look at the metaphors that Crane employed as well as Crane’s portrayal of the changing times in the West. This paper will also look at the setting and the time in the story and relate the development of the story to the underlying changes going on in the story. Crane’s short story does not contain the usual elements of the Western story but he artfully uses the genre to delight people and show the changes going on in the community of Yellow Sky. The Story The story is about the efforts of Jack Potter, the marshal of the town in bringing his new wife to Yellow Sky.He went all the way to San Antonio to fetch his wife and transported her via train. Yellow Sky is a frontier town in Texas at a time when the civilization is encroaching upon the environment of the Old West. Crane’s story had the makings of a Western—there was a train, a town in the Old West, the challenges for fights and duels as well as the bar where cowboys gather and drink. By the end of the story, however, Crane does away with the typical idea feature of a Western—the gunfight and seems to proclaim that the end of violent gunfight and duels is at an end.The story has four parts and it shows the interaction of the character with the environment and the society that he has. Surprisingly, the wife of Jack Potter does not have a name. Although she plays an important part in the story, she seems to represent only the role of women in marriage and in raising a man’s family. The first part of the story shows Jack Potter, without naming him, coming from San Antonio with his wife on a train, the â€Å"Great Pullman† traveling throughout Texas. In this section of the story, Crane masterfully shows the lack of orientation of Jack and his wife to the luxury and the elegance of the train.He portrayed them as follows: â€Å"To the minds of the pair, their surroundings reflected the glory of their marriage that morning in San Antonio. This was the environment of their new estate, and the man's face in particular beamed with an elation that made him appear ridiculous to the negro porter. This individual at times surveyed them from afar with an amused and superior grin. † (Crane 92). Clearly, the couple appeared to be simple compared with the luxurious train that they were traveling in that even the negro porter looked at them with disd ain.As the train nears Yellow Sky, Jack Porter becomes anxious and restless. Apparently, he feels guilty over leaving the town without much of an announcement of where he is going and what his purposes in leaving was. There appear to be two possibilities as to the guilt of Jack. One is that marshals of a town may not marry due to the necessities of the job that they have to perform, or that he has gone â€Å"headlong over all the social hedges† (93) by not informing his friends and his family as to his getting married.This also explains why in the story, Jack Porter leads his wife quietly to the place where they will stay. Crane then shows the two adversaries—Scratchy Wilson and Jack Porter through the eyes of the six men and the Eastern drummer at the Gentleman Saloon. As the drummer recounts a story, the door of the Saloon opens with another man saying that Scratchy Wilson is drunk and is looking for his enemy, Jack Porter. This incident builds up the expectation tha t some shooting will occur in the vicinity. Scratchy is further introduced as one of the last member of the gang to hang out in Yellow Sky.Scratchy then appears in the third part of the story and he is portrayed complete with the gun and swaying gait that cowboys have in Western stories. Stories set in the American West have already achieved the level of legend and portrays elements of heroic literature (Cortese 122). Scratchy then begins shooting in the area, which is tantamount to issuing a challenge against anyone who cares for a gunfight. He then walks from the Saloon to Jack Porter’s house and issues a warning and expletives against Jack.The last part of the story is where Scratchy and Jack Porter meet. It is situated near the house of Jack and the wife of the latter is in plain sight of Scratchy. Scratchy then challenges Jack for a gunfight. Jack responds by saying that he has no gun. Scratchy rages against Jack and says â€Å"don’t take me for no kid† (Cr ane 98). He was still expecting Jack to answer his challenge for a gunfight. Jack then talks with Scratchy, saying that he does not really have a gun. Jack Porter then made the admission that he has no gun because he has married.Because of the suddenness of it all, Scratchy could not deal with it and simply walked away and declared that â€Å"it’s all off now† (99). Works Cited Cortese, James. â€Å"Bourgeois Myth and Anti-Myth: The Western Hero of the Fifties,† SubStance, 5. 15 (1976), 122-132. Crane, Stephen. â€Å"Bride Comes to Yellow Sky,† Literature: The Human Experience, 8th edn. Ed. Richard Abcarian and Marvin Klotz. Boston: Bedford, 2002. (91–99). Petry, Alice Hall. â€Å"Crane’s the Bride Comes to Yellow Sky. † The Explicator, 42. 1 (1983) 45-47.

Monday, July 29, 2019

Overuse of antibiotics and the developement of resistant bacterial Research Paper

Overuse of antibiotics and the developement of resistant bacterial strains - Research Paper Example It seems that boundaries and distances have been shattered through these advancements in communications technology. Wars can even be fought in the same way that video games are played with the advent of UAV (Unmanned Aerial Vehicle) technology. Likewise, non-invasive and minimal invasive surgeries have also been made available wherein tumors are blasted with lasers or proton beams in order for them to be removed. Aside from doing away with open surgery, it also provides a more accurate targeting of the mass or tumor that needs to be removed (Massachusetts General Hospital 2010). Thus, there is less danger on the patient and recovery is of course faster as there is no major wound that needs to be healed. Patients can do away with stitches and the scars that accompany such a procedure. Indeed, Charles Darwin would have lauded the capability of the human species to survive and adapt. However, it is not only humans that can exhibit supremacy in survival and adaptation. Overuse of Antibio tics and the Development of Bacterial Strains Through these various improvements by the human race which have included leaps and bounds in medicine, it seems like the most minute organisms have been able to stay a step ahead or move clear of possible elimination from the food chain. Beyond the increased medical capabilities and modern healthcare management systems, viral and bacterial infections continue to be among the top downers of the human race. In fact, there has been no cure for the Human Immunodeficiency Virus or HIV which eventually morphs into the killer Acquired Immunodeficiency Syndrome or AIDS. Despite the technological advances from the last decade, a cure for this dreaded disease that comes from the late century has yet to be found, cultured or developed (Mamo et al 269). AIDS walked out of the closet in the early 80’s and by 1983, it was identified that the cause of the disease was HIV. It did not take long for the killer to become known globally and this has effectively grown into pandemic proportions infecting over 60 million people worldwide. Despite the time and money devoted to researches, a cure for this infection continues to elude medical scientists hence, posing a hanging threat to the populace. Currently though, the possibility of a cure through nanotechnology is being explored though a prospect for an effective cure seem to remain beyond the horizon. Well, for now, that may be too much to ask but the common cold also has no cure. This has been around for very long though, even before these technological advantages have ever been imagined by man. Likewise, bacterial strains have also been busy on the evolution department making many antibiotics obsolete and useless. This poses a serious threat since these microbes multiply swiftly and some have a respectable kill rate. New strains are evolving into super bugs that may eventually render even the most potent antibiotics useless. Taking a big chunk of the attention of medical scie ntists is the Acinetobacter baumannii. This bacterial strain has been found to have been capable of effectively guarding itself against even the most potent antibiotic (Peleg et al 538). This may pose another threat as the bacterial strain seems to fancy weak patients in the ICU (Intensive Care Unit). Thus, medical practitioners are trying to combat these bacteria which caused pneumonia can easily kill the weak ICU patients. A group of pharmacists tried treating

Sunday, July 28, 2019

How Latin American Music Has Developed Essay Example | Topics and Well Written Essays - 1750 words

How Latin American Music Has Developed - Essay Example The Development Process The actual origins of Latin American music cannot be traced easily, however, various explanations have been put up explaining this. Tiemstra (1992) suggests that one of the major explanations is cultural interactions: people from the European countries moved to America and were later followed by the African slaves. The two traditions together with the American one mixed and came up with an impure culture. Latin American music is a form of art which is associated with countries of Latin America, such as Cuba, and it is usually popular due to its unique rhythmical structures. Slonimsky (1946) explains it is both vocal as well as instrumental and formally derived from African traditional ceremonies. Its main characteristic is the unique rhythm it exhibits when numerous rhythms are played together to produce one exiting rhythm. Traditionally, the music was played using percussion and other string instruments like the timbales, guitar, tres, congas and the bongo (Thompson & Chase, 1947). With developments in the music industry, instruments like guitars were replaced by the piano and other instruments such as trumpets, trombones, woodwinds and the bass to play riffs and also melodies. The exiting rhythm produced in Latin music is normally called â€Å"clave† which has a pattern of 2-3, and it is the basis of all the music of Cuba (Bloomington & In Orrego, 1971). The clave can be said to be a rhythmic pattern that is syncopated which is the revolution point of the band and is normally played using two sticks. In describing the form exhibited by the Latin music Bloomington & In Orrego (1971) say that it is usually played using three main forms. One starts with a long verse of introduction which is then followed by a section known as montuno; here the band plays an instrument called vamp. This instrument is blended appropriately with other instruments such as the mambo in order to build intensity (here the front line members play riffs of the contrasting nature). Finally, the whole choir members shift their focus to the verse, and close their presentation with a coda, which is a way of closing a piece which is precise and predetermined (Tiemstra, 1992). Having described and presented what Latin music is one needs to understand the developments that have taken place in this music. Bloomington & In Orrego (1971) assert that even before the colonial era the people who were involved in this music industry were mainly the Amerindian, Europeans mainly the Iberian, Mestizo as well as Africans. It was a mixed cultured scenario and the music which was played at this time reflected a multi-cultured origin. However, the emergence of the colonial era between the 16th to 19th centuries marked a major transformation in Latin music history. Majority of the people with Amerindian origin were decima ted and many of their traditional musical instruments destroyed together with their Iberians people’s culture (Thompson & Chase, 1947). Currently, there is very little

Saturday, July 27, 2019

Discussion Board 2 EDU 626 Essay Example | Topics and Well Written Essays - 500 words

Discussion Board 2 EDU 626 - Essay Example All the materials and physical objects that an instructor might use to deliver the information to the students or participants are called instructional media. Formally, it can be defined as "the physical means via which instruction is presented to the learners" (Reiser and Dempsey, 2007- pg 18). For instance usage of a text book, computer or even the in-class physical demonstration of an instructor can be labeled as an instructional medium. In any Instruction System Design (ISD), instructional media is used to make the audience understand the delivered material. It may be used to get the participant’s attention, to invoke the imagination of the students, to or to explain the explicit/implicit instructional goals. A research-based theory or a model is termed as Instruction System Design or Development (ISD). Such a model is designed after repeated experiments with different set of conditions (Merrill & Boutwell, 1973). It is important to note that each model is entirely dependa nt on its designer’s perceptions and ones understanding of the requirements for the instructional process. Once it is decided that an instructional medium is helpful in the process, there are number of factors to be considered before selecting a particular medium. Selection should be made after careful analysis of cost, availability, and the practical implementation of the entire course syllabus.

Friday, July 26, 2019

Why is hunting Dove so special Research Paper Example | Topics and Well Written Essays - 1000 words - 1

Why is hunting Dove so special - Research Paper Example Rather, dove hunting is a harmless and unique sporting activity which if supported, would eventually culminate into infinite advantages, to the participants, the public, the government and even to the birds that are being hunted. Dove hunting has been associated with a number of issues and myths. Of late is sharply on the decrease (Decker, Enck, & Brown, 22). A number of states are against dove hunting and other states which have allowed it has got lots of restrictions on it. Dove hunting has got lots of problems in various states like Iowa and others which practice it. Firstly, dove hunting has been made to be very expensive in terms of money which is used for buying hunting license. It has also been pointed that dove hunting has little economic value which may not support the entire estate when relied on fully. Dove hunting has also been alleged that the dove species when they are decreasing in number, dove population relies on some factors which include natural conditions like extreme weather conditions, predators and predators. All these factors causes decrease in population which may affects dove species. Hunting may also affects the behavior of doves generally. When hunting becomes too much, doves may tend to migrate to places with extreme weather conditions which may expose them to diseases. There are some home steeds where the doves always migrate to when hunting and some natural conditions are severe, these places provides shelters to the doves during rainy seasons but are also very dangerous places for the doves. There are also some predators which are also in those home steeds like dogs which may in turn feed on the doves decreasing their number which also affects the species of the doves Severe restrictions on dove hunting or complete prohibition of the activity have often been justified on the grounds that dove hunting is a threat to the birds , in the sense that it would reduce the number of doves. However, it should be

Consumer Behaviour and research Essay Example | Topics and Well Written Essays - 500 words

Consumer Behaviour and research - Essay Example e promoting people of businesses need to identify on how various clients evaluate services or products although the procedure is not simple to fathom. Here the customers might have the following elements of evaluation measures in mind prices, brand and quality (Malhotra 2012). Generally, the customer is supposed to purchase that service or product which up to maximum level satisfies his or her evaluation criteria; nevertheless, yet at this phase same element might change customers decisions (Solomon 2009). Customers purchasing decision procedure does not culminate with the procurement of the service or product, it engrosses itself within post-purchase procedure. This establishes whether the purchaser is pleased with service or product purchased or not. If pleased then super word of mouth will transpire and if the buyer is not pleased, he or she will not put in a good word concerning product or service. Consumers dissatisfaction, satisfaction or delightedness rests upon a buyer’s expectations as well as the service or product quality apparent performance (Malhotra 2012). Corporate buying decision procedure comprises of the ensuing steps: problem recognition, general need description, product specification, supplier search, proposal solicitation, supplier selection, order routine specification and performance review. Problem recognition will ensue when a corporation recognizes a need or problem, which can be met by purchasing a service or product (Ghauri 2010). For instance, Thornton Company can realize that one of its products is not selling maybe because of its taste. To improve the product, Thornton will have to buy new supplies or services to rectify the problem. When an organization wishes to improve its products or services, the traits of the products and services required are clearly stated (Keegan 2010). At Thornton, for instance, to improve the taste of a product, Thornton will give a description of ingredients needed to improve that product. After

Thursday, July 25, 2019

History of money Essay Example | Topics and Well Written Essays - 1500 words

History of money - Essay Example The function of money is identifying the value of a standard measurement of goods and services. Money is used as a denominator where one can express the measure of the value of a commodity. Money is also identified as existing through human convections. For this reason, human beings have the power to change the value of money or change it. It is in the nature of money that it is identified as being subject to fluctuations due to value with all other commodities that it may be compared to. Money is, however, more stable when compared to goods. This is because good’s value is related specifically to the individuals that demand the goods. Use of money is a measure of value for establishing the proportional value that could make it possible to equalize all commodities with this standard where it is accepted and makes the community and enables exchange.The nature of money is that all commodities, things, and objects are measurable by money. Exchange of goods and services for money occur when the parties reach a common ground for agreement on exchange basing the agreement on the idea of proportionality. The nature of money allows humans to reach an agreement that serves the needs of their intercourse and interaction although it might not be possible to for different goods to be equal.The nature and condition of transactions are dependent on the good and service that the buying party wants. Since nature requires equality, where unequal individuals receive shares unequally, the significance of money in the act of exchange is demonstrated

Wednesday, July 24, 2019

What Specific Problems Could Be Created By the Permanent Assignment of Essay

What Specific Problems Could Be Created By the Permanent Assignment of a Judge to the Juvenile Division - Essay Example The researcher states that now the court administration is contemplating on whether or not it will be a wise decision to permanently assign a judge to the juvenile division. For a while, this idea might appear to be a sensible solution to the problem of increasing workload. By assigning a judge permanently to the juvenile division, the current hybrid approach of the court can be controlled considerably. Hence, the risk of increased ambiguity on the part of the court staffs will be lessened. Moreover, the efficiency of the different categories of the justice system can be increased if specialist judges are given permanent assignments to their respective area of specialization. However, every legal expect would not agree with the idea of permanent assignment. The permanent assignment may be theoretically a rewarding idea. Nevertheless, a judge who has to handle a permanent assignment is repeatedly exposed to the same type of cases. According to Baum, short term and long term specializa tions are the two most prominent categories of specialization in law. Hence, specialist judges are better trained in handling special courts and cases. Nevertheless, when some judges are given â€Å"permanent assignments to particular types of cases, including, by definition, judges who serve on specialized courts†, they face high psychological stress. This psychological stress results from repeated hearing of the same sort of cases. And if the court administrator starts to give a selected judge (particularly one who has been serving in a hybrid court system) similar cases constantly, he/she may be overwhelmed. Of course, the judge has to see the same sort of crimes, face the same sort of questions, and deal with the same branch of law (here, it is the juvenile code) all the time. In fact, when a judge is aware that he/she will have to hear the same kind of cases for a long period of time, this very reality may affect the way he/she thinks.

Tuesday, July 23, 2019

Discussion post Essay Example | Topics and Well Written Essays - 250 words - 10

Discussion post - Essay Example Diabetes therapy involves non-pharmacological and pharmacological interventions that include physical exertion (suitable exercises and work), functional feeding, self-monitoring of blood glucose, and use of medications (Napierała, Maik & Żukow, 2011). DSME (Diabetes self-management education) plays a significant role in the care and management of diabetes. Support through technology is associated with feedback on progress and change in behavior for example, use of text messages to serve as reminders to monitor blood glucose (Prescott & Boggs, 2014). Inclusion criteria of selecting the sample for the research are correct because it describes the specific individuals included in a research (Holloway & Wheeler, 2013). The quasi-experimental design is appropriate for the research because it involves participants of an intact group that is separated into two groups, which are given two different interventions. Literature review assists in the development of research questions (Brown, 2014). I agree with Liya Varghese on the discussion about the prevalence of developing a surgical site infection in a period of 30 days after a surgical process. During a surgical procedure, a patient’s skin is prepared by applying antiseptic in circles starting with the area of the incision. The most common agents used for surgical processes include chlorhexidine gluconate, iodophors, and alcohol substances (Gangi, Guth & Guermazi, 2009). Purposeful sampling used in the research is guided by the motivation of the investigation but not statistical calculations. The quasi-experimental design is appropriate because it includes a comparison and a control group in a research. The literature review will help to relate how the current research connects to other investigations (Jackson, 2015). nursing, sport, tourism, recreation and protection of human health =: Wybrane problemy

Monday, July 22, 2019

The Sweet Old Lady Called Grandma Essay Example for Free

The Sweet Old Lady Called Grandma Essay Warm, friendly, sweet, generous, and kind-hearted; these words cannot describe my grandmother enough, but they are greatly stressed in defining her beautiful character. Her short, black hair resulted in frizzy hair due to her frequent hair-dying. When walking by the kitchen I would see a tiny head of thick hair leveled with the counter, which reminded my grandmother and everyone else of how short she was. Her thin wrinkles extended and multiplied near the corners of her eyes and around her mouth when she smiled and revealed fairly straight and white teeth for a grandmother. I found her smile shy, cute, sweet, and friendly. Her brown eyes reminded me of the same eyes searching for me in the endless games of hide and seek years ago as a little child. My grandmother wasn’t your classic grandmother. She didn’t knit scarves, do jig-saw puzzles, or sew up socks. Things she did find enjoyable doing was cooking and reading her Bible. You would know my grandmother is in the house if you smell deliciousness walking through the front door. Other than cooking, my grandmother cleaned up around the house, prayed, or read her Bible for the rest of the time. My grandmother doesn’t have the best memory but she recalls reading the whole bible at least one-hundred times. She was very close in her relationship with God and cared for everyone around her. As far as I would know, my grandmother had no long-holding grudges held against her. My grandmother would also spend well over an hour in prayer for people she hardly knew. I would know because she would lecture me after prayers telling me to love my neighbors as she recited verses from the Bible. My grandmother was like a gem that was beautiful both inside and out. She shined through every corner and side, reflecting happy beams of light everywhere she went. Her presence was extremely illuminating and happiness would spread around her like dominoes heaving each other over to an inevitable collapse. Every single time I had something to ask my grandmother, she presented me a welcoming smile on her face and asked me to sit down as I would start.

Sunday, July 21, 2019

Preventative Measures for Teenage Pregnancy

Preventative Measures for Teenage Pregnancy What is your narrowed topic? Be detailed in your answer. You can use any of the versions you’ve developed for prior assignments. The narrowed topic of my research paper is preventative measures for teenage pregnancy. The two preventative measures for teenage pregnancy that I have an argument for are an increase in good parenting practices and expansion of sex education in public schools. Who is your primary audience or reader? Why? Be detailed in your answer about your audience. My first primary audience is parents because they need to know how an increase in good parenting practices can prevent teens from becoming pregnant, and what good parenting practices they can execute to become a preventative measure. My second primary audience is public school administrators and teachers because they need to know how an expansion of sex education in public schools can prevent teens from becoming pregnant, and what elements they need to include in the program to make it a preventative measure. My third primary audience is adolescents because they need to know how to take advantage of good parenting practices and sex education in public schools in order to make these preventative measures for teenage pregnancy. In a sentence or short paragraph, what is your thesis statement, including your angle? Write what will appear in your essay. My point is that an increase in good parenting practices and an expansion of sex education in public schools can be effective preventative measures to reduce instances of teenage pregnancy. Parents can be primary sex educators for children, and public schools can be secondary sex educators for children to reinforce the primary sex educators. More instances of teen pregnancy are occurring because children are not receiving the knowledge they need about sex from parents and/or public schools. What topic sentences will you use as the foundation of your communication? (If necessary, add more points.) Teenage pregnancy is a social issue that is closely linked to other social issues—poverty and income, health issues, and education. Adolescents can become educated on the subject of sex and the consequences of teenage pregnancy. Parents can become primary sex educators for their children. Public school administrators and teachers can become secondary sex educators to reinforce the primary sex educators. What method of organization and development will you use to develop your paragraphs? Introduction: â€Å"Three in ten girls will be pregnant at least once before their 20th birthday† (National Conference of State Legislatures, 2014). Will one of those three girls be your daughter, your girlfriend, your son’s girlfriend, a student at your school, or will it be you? This would not have to be a worry if society would help change that statistic. There are preventative measures that can be provided to adolescents, so we can avoid the social issue of teenage pregnancy. Teenage pregnancy is a social issue that is closely linked to other social issues—poverty and income, health issues, and education. The problem has a significant impact on society as a whole. So, what if society could help reduce this issue from occurring? An increase in good parenting practices and an expansion of sex education in public schools can be effective preventative measures to reduce instances of teenage pregnancy. If children receive more knowledge about sex from parents and/or public schools, society will start to see fewer instances of teenage pregnancy, therefore making teenage pregnancy less of a social issue. Teenage birth rates were higher prior to 1980. According to the U.S. Department of Health Human Services (2013), â€Å"Teen birth rates in the United States have declined almost continuously since the early 1990s.† There are still instances of teenage pregnancy that can be prevented in today’s world. Adolescents, parents, and public school administrators and teachers all have their part in preventing teenage pregnancy. Body: Teenage pregnancy is a social issue that is closely linked to other social issues—poverty and income, health issues, and education. Teen mothers face financial problems and most likely have to rely on public assistance. The baby can face health issues at birth and later in its life. Teen mothers rarely finish high school and hardly ever get a degree from college. Adolescents can become educated on the subject of sex and the consequences of teenage pregnancy. Teenage pregnancy affects the mother, baby, and others related to the situation. Teens need to take advantage of good parenting and sex education in public schools. Parents can become primary sex educators for their children. They need to have open and clear communication with their children about sex and relationship decisions. Parents need to include their expectations for their child’s sexual behavior. Public school administrators and teachers can become secondary sex educators to reinforce the primary sex educators. They need to include sex education classes in the school curriculum. Children can learn about safe sex and the consequences of unsafe sex. Conclusion: I will state the importance of my claim by stating main points differently than I did in the paper. I will use a dramatic closing that relates to the opening of the paper to hit on the audiences’ emotions and relevance to the topic. I will close with a memorable and logic statement that will keep the readers thinking about what actions they should take after reading the paper. Preventative Measures for Teenage Pregnancy â€Å"Three in ten girls will be pregnant at least once before their 20th birthday† (National Conference of State Legislatures, 2014). Will one of those three girls be your daughter, your girlfriend, your son’s girlfriend, a student at your school, or will it be you? This would not have to be a worry if society would help change that statistic. There are preventative measures that can be provided to adolescents, so we can avoid the social issue of teenage pregnancy. Not only has teenage pregnancy occurred many times in my hometown, but I have witnessed close friends and family members go through it as well. I have observed the consequences they face on a daily basis, the impact it has on their future, and the effects it has had on their baby. I am not an expert on the topic of teenage pregnancy, so I have included ideas from the National Conference of State Legislatures, Swierzewski, and the U.S. Department of Health Human Services. Teenage pregnancy is a social issue that is closely linked to other social issues—poverty and income, health issues, and education. The problem has a significant impact on society as a whole. So, what if society could help reduce this issue from occurring? Adolescents can become educated on the subject of sex and the consequences of teenage pregnancy by listening to their parents and taking sex education classes. Parents can become primary sex educators for their children by communicating with them about sex and relationship decisions. Public school administrators and teachers can become secondary sex educators to reinforce the primary sex educators by including sex education in the school curriculum. An increase in good parenting practices and an expansion of sex education in public schools can be effective preventative measures to reduce instances of teenage pregnancy. Good parenting practices will help children learn appropriate sexual behavior, and children will have more clear communication about life decisions with their parents. An expansion of sex education in public schools will help children learn the specifics about safe sex and the consequences about unsafe sex. If children receive more knowledge about sex from parents and/or public schools, society will start to see fewer instances of teenage pregnancy, therefore making teenage pregnancy less of a social issue. Teenage birth rates were higher prior to 1980. According to the U.S. Department of Health Human Services (2013), â€Å"Teen birth rates in the United States have declined almost continuously since the early 1990s.† â€Å"Teen pregnancy has declined 42 percent, and the teen birth rate is down 52 percent† (National Conference of State Legislatures, 2014). Even though research is showing teenage pregnancy instances are declining, â€Å"Just over 305,000 babies were born to teen girls in 2012† (U.S. Department of Health Human Services, 2013). There are still instances of teenage pregnancy that can be prevented in today’s world. Adolescents, parents, and public school administrators and teachers all have their part in preventing teenage pregnancy, but we will first address the adolescent’s part. If an adolescent is not open to learning from his or her parents or teachers, then he or she is more likely to face the consequences of teenage pregnancy. Teenage pregnancy affects the lives of the mother, the baby, and others related to the situation. According to the U.S. Department of Health Human Services (2013), â€Å"Teen mothers are less likely to finish high school, more likely to rely on public assistance, more likely to be poor as adults, and more likely to have children who have poorer educational, behavioral, and health outcomes over the course of their lives than do kids born to older parents.† â€Å"Only 40 percent of teen mothers finish high school† (National Conference of State Legislatures, 2014). Many teen mothers lose their support system or give up on their goals because they see them as impossible to reach. Babies born to teen mothers face challenges and sometimes even more than the mother. Many teenage mothers are more likely to give birth to babies with low birthweight. â€Å"Low-birthweight babies are more likely to have organs that are not fully developed, which can result in complications, such as bleeding in the brain, respiratory system disorders, and intestinal problems† (Swierzewski, 2011). Figure 1: Teenage Mother Waits for Her Premature Baby  Ã‚   Figure 1: This teenage mother is waiting to see if her premature baby made it after birth. Giving birth to premature babies is another risk of teenage pregnancy that can emotionally affect the mother and lead to health risks for the baby. Source: Swierzewski (2011). As shown in Figure 1, teenage pregnancy causes emotional stress on the teen mother, but the child is at risk for stress later on in its life as well. â€Å"Children born to teenage mothers are at an increased risk for abuse and neglect† (Swierzewski, 2011). â€Å"Boys born to teen mothers are 13 percent more likely to be incarcerated, and girls are 22 percent more likely to become teenage mothers themselves later in their lives† (Swierzewski, 2011). It is just as important for male adolescents to be knowledgeable about sex and teenage pregnancy consequences as it is for female adolescents. â€Å"An estimated nine percent—or 900,000—of young men between the ages of 12 and 16 will become fathers before their 20th birthday† (U.S. Department of Health Human Services, 2013). Now, adolescents have to decide how they will help prevent instances of teenage pregnancy from occurring. â€Å"The only certain way to avoid unwanted pregnancies is to abstain from sexual intercourse† (U.S. Department of Health Human Services, 2013). However, adolescents should be open and honest when communicating about sex to their parents and/or teachers. Adolescents should ask specific questions and request specific answers. They should make sure they are listening to the good parenting practices of their parents and take advantage of sex education classes in school. If the school does not offer sex education classes, approach an administrator or teacher to ask if classes can be an option for the school. References National Conference of State Legislatures. (2014, January 22). Teen Pregnancy Prevention. Retrieved from http://www.ncsl.org/research/health/teen-pregnancy-prevention.aspx Swierzewski, S. J., III. (2011, December 9). Teen Pregnancy. Remedy’s HealthCommunities.com. Retrieved from http://www.healthcommunities.com/teen-pregnancy/children/overview-of-teen-pregnancy.shtml U.S. Department of Health Human Services. (2013, December 20). Teen Pregnancy and Childbearing. Office of Adolescent Health. Retrieved from http://www.hhs.gov/ash/oah/adolescent-health-topics/reproductive-health/teen-pregnancy/index.html#.UufzeaHnbIU

Benefits of Music Therapy for Autism Disorder

Benefits of Music Therapy for Autism Disorder Using relevant theories and examples, analyse how music therapy can help to treat autism disorder Outline Introduction: Music therapy is rooted in the work of psychoanalysts (Freud, Jung, and Watzalwick), music teachers (Willems, Dalcroze) allied with in-depth music studies (Schaeffer, Sachs). Definition Although there are different conceptual models in music therapy, it is possible to distinguish the music practices intended only for sick patients from music practices used as a tool for personal development and are therefore accessible to all. Music therapy is a â€Å"non-verbal psychotherapy that uses corporo sonoro nonverbal expressions to develop a relationship between the therapist and those who need support to improve the quality of their lives and reintegrate into society. It also aims to produce social, cultural and educational changes in the ecosystem and to act on the primary prevention of community health. â€Å"(The Benenzon model). Music therapy comes against psychoanalytic theory which conceives language as essential to the revelation of the unconscious. It is based in fact on the development of the relationship and the therapeutic process through non-verbal communication called analogue communication by Watzalwick. Music therapy is conceived as psychotherapy, that is to say a relationship between two individuals, one of whom, by his knowledge and experience, will try to transform the other by influencing him. -The development of music therapy (historical perspectives) Most traditions all over the world in a way or another say: In the beginning was the Word. If science speaks of a big bang theory to describe the birth of the universe, it is not pure coincidence. In the Egyptian history, the god Thoth had created the world with a loud cry. In the Old Testament, it is the sound of trumpets that destroyed Jericho. From the earliest times, the sound is described as a creative or destructive element. Some of Plato and Pythagoras ideas had created a real focus on a system based on philosophical harmony. In their concept, music was part of integrated mathematics. In the Greek civilization, music therapists already existed and they were suggesting various instruments to influence the mood of people. According to the evil, they chose the aulos (old musical instrument) in an ecstatic and moving game or the sweet and harmonious lyre. Patrick Alderman (1981) Music and Medicine Stock Music. In Chinese philosophy, Confucius stated: Enjoy music, it is the formation of inner harmony.† This practice is still used by the Tibetan lamas. In Africa, traditional music, very rhythmic and loud, is used for ceremonies but also to generate altered states of mind. And since World War 1, science is having a new look at the effects of music. This research is shown mainly in the works of Anglo -Saxon authors such as Schoen and Gatewood (1927), Hevner (1936) , Carpuco (1952) and Cattell ( 1953). In parallel, several French authors focused on the meaning of music and some of them attempted to develop a theory. These include Frances, Imberty, Jost, Pratt, Simon and Werbick. Music therapy and mental illness (music as a special way of communication can help to explore the inner world of people with mental disorder?) In hospitals and retirement homes, we approach more and more people losing their autonomy with methods of music therapy. Musical instruments have a power of attraction on real people and are used more frequently to encourage older people to break their isolation by participating in musical activities in a group. People suffering from severe psychological problems respond very well to music too. Often aggressive behaviours are absorbed through music. Children with intellectual disabilities have shown to develop, it seems that music arouses in them an unexpected receptivity and currently science is exploring all avenues to develop its curative powers. -Music therapy and autism Music therapy is a relatively new method of treatment for autistic patients, but often forgotten when different options are discussed. Music therapy Patients often show improvements in temperament and learning. Music connects to the non- verbal part of our brain, making it an ideal treatment for disorders in which the patient has difficulty communicating, such as autism. Music therapy is effective because it can be used in conjunction with social skills training. Many games can be made using music to help improve the social and behavioural skills. By encouraging eye contact while singing or using instruments, music therapy can help autistic children to break down social barriers with people. Music therapy can help children and older autistic patients to develop speech skills. Music is a way to connect verbal and nonverbal functions in the brain. Autism may have various forms of speech disorders. Some can only hum, grunt, or make other noises, while others are carried to repeat absurd sentences, babbling and screaming. Others again come to develop sentences to communicate with the world, although they generally lack emotion. People with autism are known to speak in a monotone. However, no matter how the individual behaves with speech, he or she can participate in a music therapy, tapping rhythms or humming. Autism patients are generally considered particularly suitable for music therapy. Some, for example, have a very high pitch. Others may play very well a particular instrument, with little instruction. Even if your child shows no capacity to be a musical genius, you will often find that the autistic person has musical abilities beyond his other abilities. A music therapist can use music as a way to link this type of learning with other types of learning, not only for the development of language and social behavioural development as previously discussed, but also as a means to communicate their emotions and develop memory. Using these techniques in conjunction with other therapies, music therapy can do wonders with autism. Skilled professionals can use music to teach children and others how to communicate non-verbally, which makes learning easier for patients. Therapeutical approaches to autism: Music Therapy Studies have reported positive effects of music therapy with children and adolescents in the treatment of autism. The reported benefits include increased vocalizations, verbalizations, and gestures, understanding vocabulary, and attention-related task, acts of communication, symbolic play skills and personal care, as well as decreased echolalia (automatic repetition of phrases as we understand them). Researchers also observed improved body awareness and coordination, and decreased anxiety. However, results have been inconclusive in respect of the effect on the behaviour problems. It also remains important to clearly define the long-term benefits. To plan an intervention, music therapists choose their activities from a myriad of approaches and possible musical experiences (improvisation, listening to music, instrumental performance, cognitive learning through music, etc. . .) according to the autism patient. With respect to the material used, the therapist can compose music or songs himself, or draw on the repertoire of music for children; it is rich in simple ditties, has regular repeats that facilitate teaching exercises. As for musical instruments available to the participants, it can be, in addition to those used by the therapist, synthesizer, various percussion, wooden xylophone, flutes, a â€Å"rain stick â€Å"etc. . . Once the person is comfortable, the therapist can include various instruments in the exploration of the environment made by the child. Gradually, once there is a non-verbal communication through instruments, the speaker can begin to encourage a form of verbal communication directly related to the music, if the case is suitable. Favourite music can be used for a wide range of cooperation activities in order to work on social behaviour. In a group, to get a ball from one child to another, the sound of music or playing the drum set would be, for example, the means used to generate interaction. We can also practice problem solving using a dotted history of sound effects and music, etc. . . . Gradually, new measures are introduced (walking, sitting, sleeping, etc. . .) And the speaker gradually decreases its own participation. Once the music is completely eliminated, the child has been able to construct sentences in response to questions What is it? and what is the doll doing ? this learning was probably facilitated by the presence of music and the view of another associated object . Note also that, even if the words of some songs do not always appear important for everyday use, the simple fact of the match is an important step in teaching some children. According to Myra J. Staum (1997), following an interve ntion, if a student forgets the words or sentences acquired, it is conceivable to remind him by making him hear the song again. The discovery of his own body and the space around it is another aspect in which music therapy can be useful in the autistic individual. Some therapists use e.g. marches and bring the children to walk to the beat of the latter; music and a different rate is then used to ensure that subjects develop a repeating pattern when walking . Many autistic children are also invited to dance: by doing so, they are encouraged to trust the speaker, to develop a better eye contact and a greater awareness of physical contact. Similarly, dancing to different styles of music, the individual can learn to become familiar with change and synchronization, etc. . . . As a sum-up, we can see there are dozens of ways in which music can be used for therapeutic purposes for children with autism. Many aspects, from the birth of a collaboration till extended periods of attention through language acquisition or socially acceptable behaviour, are likely to be among the objectives achieved in a music therapy program ; To achieve this, you just need patience, time and a skilled speaker. improvising (group and individual) With music therapy in autism, It is not just about â€Å"playing a tune† to entertain the patient. It is a work on the sound, the waves and the vibration. It should have a large array of improvisation in all its forms, and include the greatest possible number of musical aesthetics. This includes Western and non-European modes , rhythms and varied tempos, classical sounds of the instrument and voice or sounds using harmonics, different noises , many major keys , minor , traditional , pentatonic modes , exatoniques , atonal music, a wide range of frequencies of the most serious to the most acute of the instrument etc. Active musical therapy consists of expressions with suitable music instruments. It can be self-expression or specific exercises that each has a function. We can thus work on the exchange and communication, frustration, recovery of personal image, memory and concentration improvement in cognitive abilities, body awareness, imagination and creativity, fine motor skills and body address, autonomy. dance and movement Reflection in and on the physical, emotional and subtle body is an essential element of dance therapy and movement. Through improvisation and creation, it determines new body experiences in a wider field of motion perception by more precise specificities. This practice promotes the direct expression, preverbal, nonverbal and verbal communication and the environment. It manages the senses problems and diseases based on experience, stimulating the capacity to act and personal creativity. The dance therapy and movement brings the person to a healthy dynamic. As explained Nicole Harbonnier-Topin, Professor of motion study and director of senior cycle programs of the Department of Dance at the University of Quebec at Montreal, dance therapy involves several systems of neurological function: the awakening and rest, emotional regulation, implicit and explicit memory, the mirror system and the integration of the right brain versus left brain. As the sympathetic and parasympathetic systems are involved in the process of movement, resulting in regulation of emotions that can help counteract the anxiety and some types of depression. There is indeed a body consciousness that brings us into intimate relationship with ourselves. So when we dance, there is a release of tensions and pressures which are in our body’s memory. Autism: Individuals with autism, when they apply the instructions in dance therapy sessions, find the concentration needed and make the right moves, and with an assurance that they do not necessarily have daily life. (Please use relevant theories and example to explain why these musical interventions are effective treatment for autism disorder) Criticism of music therapy So far, music therapy proved to be beneficial. It did not show any harm or any recession of the patients. Dance therapy can approach our problems gently and carefully. It is a powerful for physical and mental wellness tool. Talent is secondary to take pleasure to dance. Dance therapy Figures are diverse and this therapy has been one of the methods used in taking care of sick people and has multiple indications: the ordinary neurosis with autism, through anxiety, depression, addictions, psychosomatic diseases, psychiatric disorders, light and deep, motor and mental disabilities. All dance genres are possible. Including: bio-dance gestures based on touch and feel, reviving the notion of tenderness primitive dance succession of repetitive movements promoting relaxation of the mind. shamanic dance inspired from rituals of primitive societies. Conclusion: Music is a versatile tool for intervention with autism Music therapy has been proven beneficial in several areas: in the past it has shown its positive influence on blood pressure, pain perception, respiratory problems, stress, etc. . In the specific case of autism and people with pervasive developmental disorders, music is certainly an interesting option for several reasons. First, the music is a form of nonverbal communication; it is an ideal way to get in contact with children experiencing difficulties in communicating, which is a very common feature in autism. Non-verbal and non-threatening nature of the medium is also an asset. On the other hand, the music acts as a natural reinforcer, which can help students develop skills that are not musical; almost everyone is likely to respond positively to at least one kind of music. It is a versatile tool that can reflect the individual skills of each individual. In another area, it has been noted repeatedly that autistic individuals often have a particular sensitivity to music. Some will react to certain sounds; others however have an â€Å"absolute† ear for music, a property that would make many musicians envious! In summary, several reasons make music an interesting therapeutic tool for autism. Music captivates and holds attention- it stimulates and uses several areas of the brain. Music structures time in a clear and understandable way (â€Å"this is the song of goodbye, the session is almost over!) It provides a pleasant and meaningful context for rehearsals necessary for some learning It creates a safe and structured social context for the verbal and nonverbal communication This is a very effective memory aid It supports and encourages movement It facilitates interaction and promotes self-expression It embeds itself in memory and emotions It often promotes a sense of community since it unites people of all skill levels, all able to participate in a way or another. Bunt, L. (1994) Music Therapy: An Art beyond Words. London: Routledge.

Saturday, July 20, 2019

Industrial Revolution Essay -- essays papers

Industrial Revolution â€Å"Industrial Revolution†, in my opinion, is not a correct term. It makes it sound as though the whole thing happened at once, which it did not. It was rather an industrial evolution, or better yet an industrial chain reaction. One event impacted others and these changes impacted yet others. There were many important inventions during this time period. These inventions all made life a little easier for the people living during this time. There was an increasing demand for new material for clothing. The invention of the spinning jenny and powered loom made this possible. Steam engines provided power for machines. The cotton gin was another important invention. The Cotton gin made it possible to make clothes out of cotton, instead of the scratchy wool that clothes had always been made out of. Railroads were a very important invention during this century. Before the railroad was invented, people who lived away from their families never saw them. There simply was no easy way for them to visit. By 1869, railroads could go coast to coast in six and a half days. This is one way that the Industrial Revolution impacted social aspects of people’s lives. The Industrial Revolution did not only provide positive changes. There were also many negative changes. However, when you’re dealing with something that is going to change people’s lives to this degree, some downfalls can be expected. The industrial r...

Friday, July 19, 2019

Hey kids :: essays research papers

Hey Kids!   Ã‚  Ã‚  Ã‚  Ã‚  I know it can be hard but try to remember when we were kids how much we all loved to wake up early on Saturday morning, sneak to the T.V., and watch our favorite cartoons. We loved to do this not only so that we could see our favorite characters go through troublesome dilemmas each episode, but also that we could see what was new on the market and try to convince our parents to spare a few dollars and buy it. This tactic has been used from years upon years and will likely continue occurring for the simple reason that it works. Businessmen in the marketing know that kids will see the latest and greatest thing and insist to their parent that they must have it. And with a little persistence and maybe a temper tantrum or two, they usually get it. Sometime commercials will appeal to not only the child, but also to parents because they can see the new toys that they are able to buy for their kids. Because there is always a constant demand for new toys, there will always be a entrepreneur trying to make money by creating a product, and market it in the way of commercialization. It is a never ending cycle which will always occur as long as there is T.V. because it is how they make their money.   Ã‚  Ã‚  Ã‚  Ã‚  It had been years since I had woken up early on a Saturday morning to watch the â€Å"early bird† cartoons so when we were told to pick a show I knew what it would be, HEY ARNOLD! HEY ARNOLD! is played on NICKELODEON in the morning each day of the week. HEY ARNOLD! is a cartoon about a group of young kids that live in the city and go to school together. A similar theme that many kids can relate to. I used to watch this show as a kid and I knew that they still played it on KICKELODEON so I woke up at the same time that I used to watch it, 7:00 a.m., although it was not on until 8 a.m. it was okay. I sat down from 8 o’clock until 9 and watch two episodes of the show. When I thought about what commercials I would see I had a pretty good idea. Sitting down and watching them proved my ideas correct. Before I sat down to watch the show I made a list of types of commercials I thought would be on just to see if I would be right.

The History and Impact of the Printing Press Essay -- Technology

Everyday people read newspapers and books, but where did printing begin? The movable type printing press by Johannes Gutenberg made this all possible. Johannes first conceived of this idea of the printing press in the 15th century in order to speed up the slow process of producing books (Bantwal). The movable type printing press, the first real technology of its kind, helped to solve problems, but in turn also caused problems. This technology did influence many areas of life in its lifespan. This includes challenging the church and poisoning people with the increased toxins from mass products of materials. Depending on one’s point of view, this invention could be the best or worst thing to happen during the 15th century. Regardless of that, the printing press’s influence was widespread and therefore, was a great invention for the machine’s time. Despite the negative repercussions of Gutenberg’s movable printing press, the machine is a positive technology. Johannes Gutenberg created the printing press in the year 1452. Four other technologies that were more or less common to different parts of the world, made the printing press possible. The first technology was a wine/olive in the screw-press, which areas of Asia and Europe used to obtain oils and create wines. The second invention was block-print technology that Marco Polo originally brought to Europe. A third technology is oil-based ink that was invented in the eleven hundreds. Since this ink smears on vellum, printing did not use this ink. Vellum was costly, but durable so books that took awhile to make utilized this material. Finally, the fourth material was paper, which many process make different forms of all over the globe (Bantwal). Gutenberg used these old technologies ... ...to thank. Everyone should know the origins of many of the technologies in the world and many of those do lead straight back to the printing press. Without this invention, the world would have stayed in the dark ages for generations. People, as a species would not be anywhere close to what we have achieved. Works Cited Bantwal, Natasha. "History of the Printing Pres." Buzzle.com: Intelligent Life on the Web. Buzzle.com. Web. 19 Apr. 2012. Beach, Justin. "Pros of the Printing Press." EHow. Demand Media, 08 Apr. 2011. Web. 19 Apr. 2012. Jensen, Carolyn. "Jensen Review." Rev. of The Printing Revolution in Early Modern Europe. Lore. San Diego State University. Web. 24 Apr. 2012. "Printing Press." ThinkQuest. Oracle Foundation. Web. 22 Apr. 2012. Ross, Tiffany. "Negative Effects of the Printing Press." EHow. Demand Media, 28 Mar. 2011. Web. 19 Apr. 2012.

Thursday, July 18, 2019

Relevancy of Institutional Theory for Managers Essay

Institutional theory is one the most renowned theoretical approaches to internationalization process of firms. From the 70s, there have been publications supporting and developing this theory by researchers such as Di Maggio, Powell, Scott, Meyer or Rowan. Nonetheless, some other alternative theories, such as OLI paradigm or TCE model, have also proven themselves quite significant. Shortell and Kalunzy (2000, p. 4) state that organizations must face certain external factors such â€Å"external or societal norms, rules, and requirements that an organization must conform to, in order to receive legitimacy and support†; which are two basic factors for a successful internationalization process. Nowadays, it is essential to determine the accuracy of internationalization theories because corporations need to respond to the challenges of a globalized world. This essay aims to examine the applicability of the main assumptions of this theory in order to explain the internationalization decisions made by firms? anagers. For that purpose, key aspects such as its scope, current importance or empirical support will be evaluated. Meyer and Rowan (1977), Di Maggio and Powell (1983), and Scott (1987) state that, in order to obtain legitimacy, firms must face â€Å"isomorphic pressures† from the external context. Di Maggio and Powell (1983) define isomorphism as â€Å"constraining process that forces one unit in a population to resemble other units that face the same set of environmental conditions† and they remark that firms are forced to compete for legitimacy and political influence apart from customers and resources. Scott (1995) specified that there are three types of isomorphic pressures: regulatory, cognitive and normative. Regulatory pressures can be defined as the rules, legislation and sanctions established by government that companies must follow. Cognitive pressures refer to the shared vision of how the world works by the members of an institution or societal entity able to affect a corporation. Normative pressures can be described as the values, norms or other cultural aspects within a country that can influence a firm. In other words, for this theory, any internationalization or foreign direct investment (FDI) operation respond to a legitimacy seeking procedure in order to have access to key resources such as public funding or customer support. Nevertheless, this theory does not cover all the possible dimensions of an internalization process. Dunning (1993) states that there are 4 main motivations for an internationalization process: market seeking, resource seeking, efficiency seeking and strategic asset seeking. Market seeking can be explained as penetrate into other market and avoid dangerous factors such as tariffs or exchange rate risk. Resource seeking refers to many factors such as location in a cluster, information, or less costly or more efficient resources. Efficiency seeking can be defined as cost reduction (transport and transactions) and the economies of scope and scale that can be reached in a internationalisation process. Strategic asset seeking is all the rest of different motivations such as imitating competitors, prevent competition or follow consumers. Therefore, Institutional Theory does not seem to cover fully those aspects because no economic considerations are made under this theory. On the other hand, there are theories that cover more accurately economic considerations in internationalisation issues. Buckley and Casson (1976), and Rugman (1981); under Internalisation Theory, state that existing markets may not offer the most efficient conditions to companies and making those markets â€Å"internal† will reduce the transaction costs of operating with those markets. Dunning (1980) argues, in this OLI paradigm, that firms operate in international market in order to seek for different kind of advantages: Ownership advantages (i. e. rademark or know-how), Locating advantages (i. e. low salaries or taxation) and Internalisation advantages (same advantages mentioned in Internalisation Theory). Hence, it is obvious that Institutional theory has a limited scope as long as it covers political and social aspects of internationalisation, but it does not give any hint about economic concerns. Since the year 2000, according to a report written by the United Nations (2 013), FDI going to BRICS countries (Brazil, Russia, India, China and South Africa) has tripled reaching an amount of $263 billions in 2012. This amount represents 20% of FDI in the world. Moreover, Hall (1976) states that there are certain countries that can be described as High-context cultures that are based in interpersonal relationships. Those are countries where factors like trust or legitimacy are crucial for business and BRICS are considered as high-context countries. Therefore, firms need to gain legitimacy in order to operate in those markets and Institutional provides an excellent theoretical framework for defining success in those markets. Nonetheless, it cannot be assumed that firms just comply with external pressures in order to gain legitimacy. Di Maggio (1988) argues that agents and organizations have their own interests and have the ability to implement strategic actions in order to fulfil their ambitions. Scott (1995) also states that companies and organisations do not react in a passive way to institutional environment and they behave actively. Araujo (2000) determines that, although organisations are under external pressures, companies will decide their own response to the environment. Hence, companies are influenced by external factors, but they can decide what to do regarding those factors. On the other hand, there is some evidence that companies tend to mimic their strategic moves. Leroux, Pupion and Sahut (2011) state that companies are influenced by the choices made by the leaders of their sectors. Lieberman and Asaba (2006) argue that firms tend to imitate each other in order to deal with the uncertainty of the environment and reduce risks. For those authors, there two explanations for business imitation: information-based explanation and rivalry-based explanation. Information-based ones assume that companies imitate the ones who seem to have †superior† information. Rivalry-based ones that companies copy their strategic moves in order to limit rivalry or keep stable competitive parity. There are some researchers who have tried to deduct whether Institutional theory is reliable or not for explaining an internationalization process. Bianchi and Arnold (2004) state that Institutional theory is the best theoretical framework in order to explain the failure of the Internationalization process of the American retail company Hot Depot into the Chilean market in 1998. Their research determined that the main cause of the failure of this process was the scarcity of legitimacy of Hot Depot in Chile because they were not able to offer a confortable shop atmosphere for their customers and the range of products was not satisfactory for Chilean clients. Also, Hot Depot failed because its competitors were capable of anticipating and responding to its competitive advantage. Moreover, Cao and Perderzoli (2012) determine that institutional environment is very significant in the decision making process of retailing companies while operating in an emerging economy. They also state that the creation of shared added value in those economies and the engagement between the company and the host market will increase the adaptability of those companies to institutional environment in emerging economies. Nonetheless, there are some other papers that determine that the effect of external environment in a company depends of its profile. Walsh and Yu (2010) state that institutional factors do not have relevance in primary sector companies while they are relevant in manufacturing and services corporations as it is shown in their research using econometric methods. Additionally; Wrightley, Coe and Currah (2005) and, Bianchi and Ostele (2006) determine that retail companies are more vulnerable to institutional issues than other kinds of companies. Therefore, there is empirical evidence that shows the relevancy of this theory for corporate internationalization operations during the last 20 years. Otherwise, this relevance depends of the sector of the company and it seems to be a relation between the level of impact of institutional factors and their level of interaction with final customers. Furthermore, it is important to discuss whether Institutional Theory is relevant or not for managers. Porter (1990) and Welford (1995) affirm that the external environment makes a strong influence on corporate strategy. Aguilar (1967) states that the environment is crucial in corporate strategy and he created the ETPS (Economic, Technical, Political and Social) model, which would become PEST model in the future, in order to analyse the external environment. Learned, Christiansen, Andrews and Guth (1969) determine that external environment is crucial for business strategy as long as it is a key element of their SWOT (Strengths, Weaknesses, Opportunities and Threats) model, where Opportunities and Threats are external elements. Thus, it cannot be denied that Institutional Theory is relevant for managers because environment is crucial for any strategic planning and if managers ignore those factors, they will be destined to fail in internationalisation process. Furthermore, external pressures have relevance in other essential aspects of corporate management. Zaheer (1995) states that companies operating abroad may suffer â€Å"liability of foreignness† which are economic and social problems that can affect their performance, so they would tend to modify their organizational structure in order to make it similar to local firms? tructure. Also, Barkemeyer (2007) state that institutional pressures encourage companies to develop CSR (Corporate Social Responsibility) programmes in order to gain legitimacy in the host country. Therefore, external environment can exert a strong influence in all sorts of aspects of corporate management such as Organisation or CSR in order to be legitimate to operate in a forei gn market and managers be aware of this situation. As a conclusion, it can be said that environmental pressures are a crucial element for business performance in international markets. During the last decade, legitimacy has proven itself as a key resource in FDI processes as long as emerging economies are becoming one of the main receptors of foreign investment and, for those countries, it is necessary â€Å"being legitimate† in order to be supported by customers, local authorities and other social actors. As a contrast, this theory has some drawbacks as long as it assumes, in its early version, which companies just comply with external pressures and it does not consider in depth economic aspects. Nevertheless, in spite of those weaknesses, Institutional Theory provide an excellent theoretical framework to managers that encourage them to be sensitive to the cultural elements (aesthetics, beliefs, norms or attitudes) and macro environment of their host markets, so they can improve their performance. Therefore, being able to provide such an important capacity to international managers is the best strength of this theory and it is what makes it relevant today.

Wednesday, July 17, 2019

A Scanner Darkly

Ashlyn Phillips Mr. Flanigan/ Dystopian Literature degree 2 December 4, 2012 Who Are You? As young children we develop to develop a nature, wholeness that is found off of the mickle we ar surrounded with. When identifying who we be as people, animal(prenominal) appearance is less definitive in comparison to our spirits and mindsets. The physical structure serves except as a hoot for our spirits and minds, without these deuce assets our bodies would simply only be empty shells. In Philip K.Dicks A Scanner Darkly, the protagonist, go after Arctor, has f solely victim to a highly habit-forming drug called Substance D, which has the side egress of splitting the record in unmatch suitables mind. In dealing with the poke fun of this drug, Arctor begins to lose himself and forgets what really makes him who he is. Our intelligences, portion and appearance determine who we are as people, without these three attributes it would be very ticklish to pit between iodine be nevolent from the next.The brain begins to develop in the initial trimester of pregnancy, even as fetuses we are qualified to think and begin to develop our personfulnessalities intimate the womb. As we enter the conception and begin living, our surrounding environments control the outcomes of our minds, bodies and spirits. If you are born(p) into a wealthy family, it is more(prenominal) than liable(predicate) that you testament live a wealthy carriagestyle if you are born into a poor family, it is more than deally that you forget live a poor livenessstyle.In society, we are first identified by how more money we have, because by how we touch sensation and at last we begin to meditate more about separately early(a) to identify who our characters are through how we wishing to portray ourselves. Our personalities begin to develop when we are first able to open our eyes, smiling and really when we begin to communicate with for each one other. From there we begin to learn what we like to do in life whether it be dancing, singing, painting, playing sports, etc.These attributes are major when identifying a person. Our spirits begin to develop at an early age and although they can be slenderly altered as life goes on, we never really change entirely. angiotensin-converting enzyme can be judged by their physical appearance and be separated from one person to the next simply based on that, however, if asked who dock Marley is as a person, the answer would be far more detailed than if only asked what he looks like. record and character traits are really the ground of find who we are as people.If a set of identical twins were format in the same room in concert and a group of people were asked to differentiate between Sarah and Mary, they would only be able to based on appearance. The more in depth call into question would be, how can you guarantee who Sarah is and who Mary is? In answering this question many key attributes are discussed m uch(prenominal) as, Sarah may be more energetic, loud, creative, talkative, religious and athletic than Mary, allowing for their friends to automatically know who is who when confronted by either twin.Personality always gives the answer. If the personality changes or begins to morph into two different sides, determining who some consistence is becomes a very concentrated task. In A Scanner Darkly, Fred goes hugger-mugger as a drug drug addict in order to solve a major case but in doing so, he himself becomes addicted to the drug and his personality begins to split into two different people, Fred and phellem Fred being the undercover cop and Bob being the addict.As Freds life morphs into Bobs, he begins to lose himself entirely and the adult male as he knew it before all changes into something different than he thought. He impart sink into a needle-and-a-spoon existence, or outflow off the walls in a psychiatric hospital or, worst of all, a national clinicAnd all this give occur deliberately, someone figured out what he was doing and then got him this way. The worst way of all with the overindulge they sell that he was after them for selling. (86) His personality can no longer be analyzed because he thinks as two entirely different people as if he has two separate brains in one head. Clearly this is an issue repayable to the fact that we are recognized by our personalities. If two personalities are competing against one other inside of one mind, there is no way to really know who that person is. Fred loses himself in Bobs world and the drug becomes more important than anything else, as it usually does inside the mind of a drug addict.Without the head, the body is like a light bulb without electricity. The soul gives the body meaning and purpose, without it there would only be boys and girls, non unique individuals with their own characteristics. The soul carries along every memory, experience, encounter, and detail of each person in the world. A quick-scented soul will think beyond their years, a young soul will stay a teenager at heart forever and an evil soul will end up in the dark side of life and all of these souls grow through life experiences and will only be influenced by these experiences.The soul in one person does not change entirely through life experiences it can only change slightly by being influenced by those near us. In determining who we are as people, the soul is the key ingredient and it should be the first thing that is analyzed from one human being to the next. More a great deal than not, looks do not matter, it is what lies within ourselves that determines who we are as individuals.

Monday, July 15, 2019

Ballyhoo, Prosperity and the Crash

The with child(p) slack which came by and by the break defeat of 1929 diverged the Statesn attitudes from optimism, nearthing that the Statesns had be take of the incr quilt bleed of consumer cheeseparings and because of this bracing correct focussing of spiritedness to, desperation. This stinting despair was the weather and bleakest prison term in the Statesn record. Factories closed, machines send amodal value silent, and millions upon millions of lot walked the streets, t integrity for jobs that did non be (750). immutable for hug drug geezerhood it took tot totally(prenominal)y all over all(prenominal) aspect of the Statesn deportment history.Along with this came a trade in governing that would surpass mien to a elective volume and upstage republican give way since the 1890s. Immigrants who had came to America in the rootagely indue WWI took a semi semipolitical stance that lasted by means of this rough date on through and through to the contiguous quantifys that resulted in the choice of Franklin D. Roosevelt. unmatched of the first things his responsibility did was ontogeny The refreshful mussiness. This would shape programs of easiness, reco very, and tame that greatly change magnitude the graphic symbol of political science in American life (750) in an cause to ease paltry and write down the running for scotchalal recovery.In place to sym caterpillar trackize what happened sparingally during this age a maltreat at argument organisation and organisation attitudes during the 20s should be examined. During the 20s Republicans apply their lapse to indicator aft(prenominal)wards WWI to give up supercharge mitigate enactment and to prepare a palsy-walsy human alliance in the midst of authorities and business (742). This relationship light-emitting diode to spurious beliefs in frugal fruit and stability. The machine and gismo industries during this railroad cartridge clip ca utilise a fertilisation of the grocery place. This slowed sales steadily and in 1927 on that point was a kooky recession.The owners of these industries could reserve embossed fee or bring down prices in an parturiency to puddle acquire male monarch and hold on onto the consumer-goods regeneration (750) simply unheeded the signs. The establishment could form assistanted by tenia installment- get and backwardness imprecate loans that could devour fox the slump non last as long, besides didnt. The notwithstanding unveiling that aphorism a doable difficulty and try to do something to the highest degree it was The federal killicial give bestride. The federal official make Board sawing machine problems and tried and true to shake the parsimoniousness by take down the send a track rate, and charging banks less(prenominal) for loans.This pointless trust that was addicted was opinion to be utilise for re-investment howe ver sooner went into the blood line mart that was pinch off a revolutionary fly high of guessing that obscured the maturement economic lag and ensured a remote greater doss to fall down (751). Everyone jumped on the bandwagon as the 1920s became purify know as the get-rich-quick era. Millions of individuals from all the way at the spend to all the way at the diffuse play the extractions. Anyone with extra specie was investment funds heavily in the demarcation markets. They were depend that the enormous upraise in trade protection prices would make them abundant profits.Savings were utilise to bet on the defective rail lines. Corporations apply their gargantuan funds reserves to offer property to brokers who in moment loaned it to investors on the margin. (751). By 1929 the social unit domain was in know with melodic line meditation. Offices open in huge numbers in metropolis afterward urban center crosswise America and pile flocked to them in hopes of riches. This depicted object fixation with the wangle market gave a dishonorable composition that the economic system was water-loving and this caused a cunning midsection towards the mistakes that were adventure that would head for the hills to mishap.It was in October of 1929 that effect the reverse to this coercion of speculation stock profaneing. nightlong corporations and financial institutions no interminable would run great for stock market purchases and this overly do investors and bankers menstruation bragging(a) consumer credit. This stop consumer buying place and hint to a lancinate side of meat downwardly of sales of consumer goods economic disaster that go on for 4 years. 1932 showed a age that unemployment had bighearted to 25 pct of the uncontaminating gouge.Steel takings was down to 12 part of mental ability and the capacious con feast lines in Detroit produced provided a slaver of cars for each one day. (751) in that respect were many a(prenominal) lend factors toward the path of the peachy Depression, merely the star virtually distinguished was that factories produced lots goods than they were consuming. roughly others were coseismal economic conditions in Europe, the sylvan winnow out since 1919, integrated mismanagement and of course over speculation. Americans didnt gift the capital to buy any much.Even though intimately Americans didnt present a car or a icebox the cash comely wasnt in that location anyto a greater extent. withal much specie had at rest(p) into profits, dividends and industrial expansion. not plentiful went into the turn over of the workers who would reverse the consumer. takings vs. pulverization productivity did not sufficient out. grind productivity had change magnitude 43 portion during the decade, herculeanly the recompense of industrial workers had sole(prenominal) fore gone(p) up 11 pct (752). If all the money that was used for speculation had gone to improver honorarium so consumer buy would befool gone up.This would claim created a ratio in output signal and consumption. It was sole(prenominal) after a good timbre at what happened would the consumer-goods parsimoniousness of America be understood. non lonesome(prenominal) did this cause a huge ill fortune for the world it besides showed a scrap for political ternionership in America. When Roosevelt took great power the terra firma was go up an economic cave in with unemployment at long dozen million. His first step was to free the banks. He drafted new-sprung(prenominal) general assembly for banking that would dish the stronger banks to reopen with governance swear out and force the weaker banks to close.Roosevelt launched freshly occupy programs that would service of process in industrial and agricultural recovery, cardinal of the hardest economic handle hit. This unseasoned chaw economic aided wit h straightaway problems that were some in the 1930s with programs that address relief in unemployment and desolate citizens. exactly in 1935 rectify took the place of recovery and relief. Roosevelt was growth a broker-state fancy of politics, responding to compels from unionized elements much(prenominal) as corporations, tire out unions, and maturate groups succession ignoring the involve and necessitys of the homeless who had no clear political portion (761).This caused a major(ip) pressure for change because it did not help the median(a) clapperclaw and was meant more for sexual government change. The in the altogether engage did nonplus an captivate on the quality of life in America, tho excessively had some downfall. childbed unions was one influenced that changed history along with the institution of well-disposed Security, scarce the vernal Deal seemed to only help the more forthright and organized groups and remaining minorities out. solely bl and Roosevelts intrusion on U. S.politics lead to the excite of the American stack at a time when it was desperately ask in secern to populate during a very perturbing and hard time. I preceptort penury to see it was esurience that caused this problem, nevertheless or else a take breathing in of the want of something better. Isnt that the American inspiration? adduce Divine, R. A. , Breen, T. H. , Fredrickson, G. M. , & Williams, R. H. (1987). America sometime(prenominal) and ease up 2nd. Ed. Illinois Scott, Foresman and Company.